Short‐Term Risk of Cardiovascular Events in People Newly Diagnosed With Gout
Main finding · Cardiovascular events (SCCS)Result — go to the resultAdjusted incidence rate ratio 1.55 95% CI 1.33–1.83Authors' conclusion
Individuals had a short-term increased risk of cardiovascular events in the 30 days following the first consultation at which gout was diagnosed.
Study context
- Population
- Individuals with a new diagnosis of gout in primary or secondary care, UK, January 1, 1997 to December 31, 2020SCCS 4,398
- Exposure
- 30 days after first gout diagnosis vs baseline (SCCS) and vs days 31 to 730 after diagnosis (cohort)
- Outcome
- Cardiovascular events: composite of fatal and nonfatal MI, ischemic or hemorrhagic stroke, and transient ischemic attack
Methodological detailslinked primary care, hospitalization and mortality records (CPRD-GOLD)
- Linked primary care, hospitalization and mortality records (CPRD-GOLD)
Main finding
Cardiovascular events (SCCS) · 30 days after first gout diagnosis
Adjusted incidence rate ratio
1.55
95% CI 1.33–1.83
30 days after diagnosisvs Baseline
adjusted IRR 1.55 (95% CI 1.33–1.83)
As reported in the abstract
Observational data: associations, not effects.
Further findings
| Outcome | Days 31 to 730 | Rate difference (events per 1,000 person-years) (95% CI) | |
|---|---|---|---|
| Cardiovascular event incidence (cohort study)Days 31 to 730vs 30 days after diagnosis | 21.6 (95% CI 20.8–22.4) events per 1,000 person-years | −9.6 (−14.0 to −5.1) | |
| −20−10010Difference, events per 1,000 person-years (linear scale) |
- Cardiovascular event incidence (cohort study): 30 days after diagnosis 31.2 (95% CI 27.1–35.9) events per 1,000 person-years
- Cardiovascular event incidence (cohort study): 76,440 patients (72.9% male, mean age 63.2 years)
Original publication
Short‐Term Risk of Cardiovascular Events in People Newly Diagnosed With Gout. Arthritis Rheumatol. Published 17 October 2024. doi:10.
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