Ten-year cardiovascular risk changes and major adverse events in gout patients
An erratum to this article was published (Rheumatology (Oxford), 3 Jun 2026 ↗)
Authors' conclusion
Gout patients had a high risk of incident CV events even after adjusting for CV risk profiles and their long-term changes. These long-term changes additively increase the risk of CV events in gout patients.
Study context
- Population
- Patients aged 20–90 years newly diagnosed with gout after January 2012 and matched controls; Korean National Health Insurance claims database and National Health Screening Program
- Participants
- 113,853 vs 1,138,530
- Exposure
- Gout vs age- and sex-matched controls without gout
- Goutn = 113,853
- Matched controlsn = 1,138,530reference
- Outcome
- Incident CV events (MI, cerebral infarction and cerebral haemorrhage) and all-cause death
Methodological detailsage- and sex-matched controls, multivariable analysis, adjusted for cardiovascular (CV) risk profiles 10 years before gout diagnosis and their long-term changes
- Age- and sex-matched controls
- Multivariable analysis
- Adjusted for CV risk profiles 10 years before gout diagnosis and their long-term changes
Main finding
As reported in the abstract
- MI
- HR 1.39; P < 0.001
- Cerebral infarction
- HR 1.36; P < 0.001
- Cerebral haemorrhage
- HR 1.50; P < 0.001
- All-cause death
- HR 1.07; P = 0.004
Observational data: associations, not effects.
Further findings
Interactions with 10-year CV risk profile changes
- MI: interaction with Grade 1 aggravation over 10 years of DBP
- P = 0.042
- Cerebral infarction: interaction with Grade 2 aggravation over 10 years of DBP
- P = 0.037
- Cerebral haemorrhage: interaction with Grade 2 aggravation over 10 years of total cholesterol
- P = 0.057
- Described as significant interactions
Original publication
Ten-year cardiovascular risk changes and major adverse events in gout patients. Rheumatology (Oxford). Published 14 September 2025. doi:10.
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