Changes in alcohol intake and serum urate changes: longitudinal analyses of annual medical examination database
Authors' conclusion
This study revealed changes in alcohol intake had small associations with SU change at the general Japanese population level. Complete discontinuation of alcohol in hyperuricemic participants had only modest improvement in SU.
Study context
- Population
- Annual medical examination data, October 2012 to October 2022, Japanese preventive medicine centre (median age 47.0 years; 55% women; 58.6% regular alcohol drinkers)
- Participants
- 63,486 participants370,572 visits
- Exposure
- Changes in alcohol intake between two consecutive visits
- Outcome
- Association of SU changes with alcohol intake changes
Methodological detailslongitudinal, single-centre, mixed-effect linear regression adjusted for relevant covariates
- Longitudinal
- Single-centre
- Mixed-effect linear regression adjusted for relevant covariates
Main finding
As reported in the abstract
SU change per one daily alcohol intake decrease
Serum urate (SU) change per one daily drink decrease (clinically small association), 95% CI −0.021 to −0.017
−0.019 mg/dL
Observational data: associations, not effects.
Further findings
SU change per one beer decrease (largest association)
- SU change per one beer decrease, 95% CI −0.039 to −0.032
- −0.036 mg/dL
Complete discontinuation of any alcohol (from mean 0.8 drinks/day)
- SU change, 95% CI −0.068 to −0.043
- −0.056 mg/dL
Complete alcohol discontinuation in hyperuricemic participants (subgroup; from mean 1.0 drinks/day)
- SU change, 95% CI −0.154 to −0.066
- −0.110 mg/dL
Original publication
Changes in alcohol intake and serum urate changes: longitudinal analyses of annual medical examination database. Ann Rheum Dis. Published 15 July 2024. doi:10.
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