Longitudinal Changes in Serum Urate Levels From Premenopause Through Postmenopause: Interrupted Time‐Series Analyses
Main finding · Mean SU levelResult — go to the resultDifference 0.41 mg/dL 95% CI 0.38–0.43Authors' conclusion
SU levels rapidly increase during perimenopause and are already elevated by the time of menopause.
Study context
- Population
- Japanese women with annual medical examinations, April 2004 to September 2024, with at least one visit before and after self-reported menopause
- Participants
- 8,169 women93,511 visits
- Exposure
- Postmenopause and perimenopause vs premenopause
- Outcome
- Longitudinal changes in serum urate (SU) and hyperuricemia (SU ≥6.8 mg/dL or taking medications for gout or HU)
Methodological detailsinterrupted time-series analyses, stratified subgroups
- Interrupted time-series analyses
- Stratified subgroups
Main finding
Mean SU level
Difference
0.41 mg/dL
95% CI 0.38–0.43
Postmenopausevs Premenopause
difference 0.41 mg/dL (95% CI 0.38–0.43)
As reported in the abstract
Observational data: associations, not effects.
Further findings
| Outcome | Premenopause | Postmenopause |
|---|---|---|
| HU prevalence | <1.0% | 4% to 5% |
Association of low eGFR (<60 mL/min per 1.73 m²) and high BMI (≥25) with hyperuricemia (HU) (subgroups)
- HU in overweight or obese women at menopause
- ≈18%
- Associations greater in postmenopause than premenopause
Original publication
Longitudinal Changes in Serum Urate Levels From Premenopause Through Postmenopause: Interrupted Time‐Series Analyses. Arthritis Rheumatol. Published 25 January 2026. doi:10.
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