Triglyceride-Glucose Index for predicting gout flare risk post-urate-lowering therapy: a prospective cohort study
Authors' conclusion
The TyG index can serve as an effective predictor of gout flare risk after ULT, with those having a high TyG index exhibiting a higher risk, which might be related to the insulin resistance status.
Study context
- Population
- Gout patients receiving standardised urate-lowering therapy (ULT) (febuxostat + low-dose colchicine)362 completed follow-up
- Participants
- 384 patients
- Exposure
- High vs moderate vs low baseline triglyceride-glucose (TyG) index, all on standardised ULT
- Outcome
- Gout flare risk (frequency of gout flares) after ULT
- Follow-up
- 12 weeks
Methodological detailsstratified by baseline TyG index
- Stratified by baseline TyG index
Main finding
As reported in the abstract
Frequency of gout flares
High TyG index
0.975
Moderate TyG index
0.632
Low TyG index
0.419
P < 0.001
Observational data: associations, not effects.
Further findings
| Outcome | High TyG index | Low TyG index | P value |
|---|---|---|---|
| Achievement of target SU level (<6 mg/dL) · week 4High TyG index vs Low TyG index · significantly lower in high TyG index group | 17.6% | 34.2% | P < 0.01 |
Achievement of target SU level (<6 mg/dL) · week 8 or week 12
- No significant differences among the three groups
Original publication
Triglyceride-Glucose Index for predicting gout flare risk post-urate-lowering therapy: a prospective cohort study. Clin Exp Rheumatol. Published 25 January 2026. doi:10.
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