Accelerometer-derived physical activity patterns and risk of incident gout: a prospective cohort study of 97,387 UK Biobank participants
Authors' conclusion
While any moderate-to-vigorous physical activity is beneficial, the regularly active pattern demonstrates a more robust inverse association with gout than the weekend warrior pattern.
Study context
- Population
- Gout-free UK Biobank participants with 7-day wrist-worn accelerometer data833 gout cases
- Participants
- 97,387 participants
- Exposure
- Regularly active and weekend warrior physical activity (PA) patterns vs inactive pattern
- Outcome
- Incident gout
Methodological detailsaccelerometer-derived physical activity, multivariable Cox models, subgroup and sensitivity analyses, genetic risk strata
- Accelerometer-derived physical activity
- Multivariable Cox models
- Subgroup and sensitivity analyses
- Genetic risk strata
Main finding
As reported in the abstract
median 8.0 years' follow-up
Each group vs inactiveHazard ratio (95% CI)P value
RAminimally adjusted
0.67(0.55–0.83)
P < 0.001WWminimally adjusted
0.76(0.65–0.89)
P < 0.001RAfurther adjusted for baseline sUA
0.79(0.65–0.98)
P = 0.029WWfurther adjusted for baseline sUA; attenuated, not significant
0.93(0.79–1.08)
P = 0.331Observational data: associations, not effects.
Further findings
Incident gout by comorbidity (subgroups)
- Significant interactions with comorbidities
- P for interaction < 0.01
- Weekend warrior (WW) showed no inverse association in participants with hypertension or CKD, while regularly active (RA) remained protective
Sensitivity analyses and genetic risk strata
- Findings robust across sensitivity analyses and genetic risk strata
Original publication
Accelerometer-derived physical activity patterns and risk of incident gout: a prospective cohort study of 97,387 UK Biobank participants. Arthritis Res Ther. Published 26 December 2025. doi:10.
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