Genetic susceptibility, walking activity and the risk of incident gout
Authors' conclusion
Higher walking activity was associated with a lower risk of gout across all levels of genetic predisposition, with the strongest effects observed in individuals with high genetic susceptibility.
Study context
- Population
- Gout-free participants aged 40–70 years from the UK Biobank (mean age 61.9 years; 57.3% women)672 developed gout
- Participants
- 86,930 participants
- Exposure
- Moderate and high vs low walking activity, within each polygenic risk scores (PRS) stratum
- Outcome
- Incident gout
- Follow-up
- 7-year follow-up
Methodological detailsPRS-stratified (tertiles), 7-day accelerometer recordings
- PRS-stratified (tertiles)
- 7-day accelerometer recordings
Main finding
As reported in the abstract
Incident gout, high PRS stratum · 7 years
Each group vs low walkingHazard ratio (95% CI)
Moderate walking7-year RD −0.64% (95% CI −1.00%, −0.27%)
0.68(0.53–0.87)
High walking7-year RD −0.81% (95% CI −1.18%, −0.45%)
0.55(0.40–0.75)
Observational data: associations, not effects.
Further findings
- Higher walking intensity associated with reduced gout risk across all PRS strata, more pronounced in high PRS stratum
- P for additive interaction = 0.05
Original publication
Genetic susceptibility, walking activity and the risk of incident gout. Rheumatology (Oxford). Published 26 December 2025. doi:10.
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