Cardiovascular risk according to genetic predisposition to gout, lifestyle and metabolic health across prospective European and Korean cohorts
Authors' conclusion
Our findings indicate that a higher genetic risk of gout is significantly associated with an increased risk of CVD. Moreover, adherence to a favourable lifestyle can significantly reduce CVD risk, particularly in individuals with high genetic risk.
Study context
- Population
- Participants of European descent from the UK Biobank and of East Asian descent from the Korean Genome and Epidemiology Study224,689 UK Biobank
- Exposure
- High vs low genetic risk for gout, by lifestyle and metabolic syndrome (MetS)
- Outcome
- Incident CVD
Methodological detailstwo prospective cohorts of different ancestries, polygenic risk score
- Two prospective cohorts of different ancestries
- Polygenic risk score
Main finding
As reported in the abstract
- Individuals at high genetic risk for gout had a higher risk of incident cardiovascular disease (CVD) than those with low genetic risk across ancestry
Observational data: associations, not effects.
Further findings
Incident CVD with ideal MetS and favourable lifestyle habits (low and high genetic risk)
| HR (95% CI) | P value | ||
|---|---|---|---|
| Ideal MetS and favourable lifestyleReduction in CVD risk by up to 62% | 0.38 (0.31–0.46) | P < 0.001 | |
| 0.20.5125Hazard ratio (log scale) |
Original publication
Cardiovascular risk according to genetic predisposition to gout, lifestyle and metabolic health across prospective European and Korean cohorts. RMD Open. Published 8 October 2024. doi:10.
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