Genetic contributions to female gout and hyperuricaemia using genome-wide association study and polygenic risk score analyses
Authors' conclusion
The variants in gene SLC2A9 are the major genetic factors for females associated with gout in those aged ≥50.
Study context
- Population
- Females from Taiwan biobank and China Medical University Hospital
- Participants
- 59,472 females
- Comparison
- Gout and asymptomatic hyperuricaemia vs normouricemia controls
- Outcome
- Genetic variants and PRS relating to female gout and AH
Methodological detailsdiscovery and replication cohorts, polygenic risk score analysis, stratified by age 50 years
- Discovery and replication cohorts
- Polygenic risk score analysis
- Stratified by age 50 years
Performance
As reported in the abstract
Further findings
- Variance of gout explained by polygenic risk score (PRS) in variants with protective effects
- ∼0.59% to 0.89%
- Mean PRS in risk variants, gout (times)
- 6.2
- Mean PRS in risk variants, asymptomatic hyperuricaemia (AH) (times)
- 1.2
- Dose-response trend between AH rates and PRS quartile scores
Original publication
Genetic contributions to female gout and hyperuricaemia using genome-wide association study and polygenic risk score analyses. Rheumatology (Oxford). Published 27 June 2022. doi:10.
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