Upregulated expression of FFAR2 and SOC3 genes is associated with gout
Authors' conclusion
FFAR2 upregulation is associated with gout and may trigger gout flares.
Study context
- Population
- People with normal serum urate (SU), asymptomatic hyperuricaemia (AH) ± MSU crystal deposition, or gout flare69 with AH ± MSU deposition
- Participants
- 120 people
- Exposure
- Gout flare and inter-critical gout vs normal SU, AH and AH + MSU crystal deposition
- Normal SUn = 34reference
- Inter-critical goutn = 16
- Gout flaren = 17
- Outcome
- FFAR2 and SOCS3 gene expression (RT-qPCR, fold change after normalisation to reference gene)
Main finding
As reported in the abstract
FFAR2 expression (fold changes (FC))
Gout flare vs Normal SU, AH, AH + MSU: P < 0.0001 for each comparison · Inter-critical gout vs Normal SU, AH, AH + MSU: P < 0.001 for each comparison
Observational data: associations, not effects.
Further findings
SOCS3 expression (FC) — Gout flare vs Normal SU, AH, AH + MSU
P < 0.0001 for each comparison
| Outcome | P value |
|---|---|
| SOCS3 expression (FC)Inter-critical gout vs Normal SU | P = 0.02 |
| SOCS3 expression (FC)Inter-critical gout vs AH · comparator FC printed as 1.2 in this comparison | P = 0.006 |
Correlation of SOCS3 expression with flare duration
- Negative correlation, r
- −0.49
- P < 0.05
Original publication
Upregulated expression of FFAR2 and SOC3 genes is associated with gout. Rheumatology (Oxford). Published 22 June 2022. doi:10.
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