The frequency of synovitis and calcium pyrophosphate deposition with ultrasound is increased in transfusion-dependent beta-thalassaemia patients: effect of iron accumulation?
Authors' conclusion
The presence of synovitis and TFC-CC with the US is common in patients with beta-thalassaemia who have had recurrent blood transfusions.
Study context
- Population
- Beta-thalassaemia patients (thalassaemia major and minor), wrist ultrasound (US)46 major, 41 minor
- Participants
- 87 patients
- Exposure
- Transfusion dependant (TD) vs TND beta-thalassaemia
- Outcome
- Frequency of synovitis and CPDD with US in the wrists
Methodological detailsbilateral wrist US
- Bilateral wrist US
Main finding
As reported in the abstract
Moderate/severe synovitis on US
- TD vs TND: P < 0.001
- TD vs TND: P = 0.006
- TD vs TND: P < 0.001
Observational data: associations, not effects.
Further findings
TFC-CC on US
P < 0.001
Correlation of ferritin with US scores
- Ferritin vs synovial hypertrophy (SH) score, r (p<0.001)
- 0.414
- Ferritin vs PD score, r (p=0.009)
- 0.279
- Ferritin vs combined synovitis score, r (p<0.001)
- 0.402
Factors associated with moderate/severe combined synovitis
- Ferritin level, OR
- 1.001 (CI 1.000-1.002)
- Presence of TFC-CC, OR
- 25.048 (CI 5.187-120.951)
Original publication
The frequency of synovitis and calcium pyrophosphate deposition with ultrasound is increased in transfusion-dependent beta-thalassaemia patients: effect of iron accumulation? Clin Exp Rheumatol. Published 28 March 2022. doi:10.
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