Co-occurrence of rheumatoid arthritis and calcium pyrophosphate deposition disease: A systematic literature review
Authors' conclusion
While the studies were small, RA, which is commonly seronegative, and CPPD can co-exist in the elderly.
Study context
- Population
- Patients with both rheumatoid arthritis (RA) and CPPD disease, studies published in English 1965–2026
- Participants
- 404 patients24 studies
- Outcome
- Epidemiology and clinical characteristics of patients with both RA and CPPD
Methodological details12 cross-sectional studies, 2 case series, 10 case reports, Search from database inception to 31st January 2026 in EMBASE, MEDLINE, Scopus, PubMed, CINAHL and Cochrane
- 12 cross-sectional studies, 2 case series, 10 case reports
- Search from database inception to 31st January 2026 in EMBASE, MEDLINE, Scopus, PubMed, CINAHL and Cochrane
Main finding
As reported in the abstract
- Aged over 60 years
- 397/404 (98.3%)
- Seronegative for both rheumatoid factor (RF) and anti-citrullinated protein antibody (ACPA) (of 365 with serostatus data)
- 204/339 (60.2%)
- Radiographic chondrocalcinosis
- 271/287 (94.4%)
- Seronegative for both RF and ACPA among 271 with chondrocalcinosis
- 162 (59.8%)
- MTX prescribed
- 75/205 (36.6%)
- Prednisolone prescribed
- 64/205 (31.2%)
- Colchicine prescribed
- 24/205 (11.7%)
Observational data: associations, not effects.
Original publication
Co-occurrence of rheumatoid arthritis and calcium pyrophosphate deposition disease: A systematic literature review. Semin Arthritis Rheum. Published 29 July 2026. doi:10.
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