Characteristics and long-term outcomes of patients with rheumatoid arthritis and concurrent calcium pyrophosphate deposition disease
Authors' conclusion
Seronegative RA patients with CPPD changed therapies more frequently, used more prednisone, and had worse long-term outcomes.
Study context
- Population
- U.S. veterans with rheumatoid arthritis (RA) in the Veteran's Affairs RA (VARA) registry
- Participants
- 2,771 veterans
- Exposure
- RA with concurrent CPPD vs RA without CPPD
- CPPDn = 64
- Outcome
- Low disease activity, prednisone use and new b/tsDMARD initiation over follow-up
Methodological detailsregistry-based (VARA registry), multivariable logistic regression, stratified by autoantibody status
- Registry-based (VARA registry)
- Multivariable logistic regression
- Stratified by autoantibody status
Main finding
As reported in the abstract
Low disease activity over time
- CPPD numerically less likely to achieve low disease activity over time; not statistically significant
Observational data: associations, not effects.
Further findings
| Outcome | OR (95% CI) | |
|---|---|---|
| Prednisone use, seronegative patients (subgroup) · over follow-up | 2.44 (1.15–5.22) | |
| Initiation of new b/tsDMARDs, seronegative patients (subgroup) · over follow-up | 2.79 (1.46–5.32) | |
| 0.20.5125Odds ratio (log scale) |
Low disease activity over follow-up
- Those with CPPD were numerically less likely to achieve low disease activity over time; not statistically significant
Age at enrollment, CPPD vs RA alone
- Patients with CPPD were older
- 68.5 (9.0) v. 64.2 (11.0), p < 0.001
Osteoarthritis at enrollment, CPPD vs RA alone
- Higher rate of OA in patients with CPPD
- 93.8 % v. 80.1 %, p = 0.007
- Spine disease and diabetes also more common (no numbers)
ACPA positivity at enrollment, CPPD vs RA alone
- Patients with CPPD less likely to have ACPA
- 63.5 % v. 77.8 %, p = 0.01
Joint replacement and death, seronegative patients (subgroup) · during follow-up
- Higher rates of joint replacement and death in CPPD patients
Original publication
Characteristics and long-term outcomes of patients with rheumatoid arthritis and concurrent calcium pyrophosphate deposition disease. Semin Arthritis Rheum. Published 29 December 2025. doi:10.
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