Association between serum free fatty acid levels and tophus in patients with gout: a cross‐sectional study
Authors' conclusion
High FFA levels are independently associated with tophus risk and FFA may promote tophi deposition by lowering urine pH. Serum FFA levels have a great screening value to identify tophus.
Study context
- Population
- Patients with gout aged 18 to 80, enrolled June 2018 to August 2021
- Participants
- 595 patients
- Exposure
- Serum free fatty acid (FFA) quartiles Q2, Q3 and Q4 vs Q1
- Outcome
- Tophus
Methodological detailsmultivariate logistic regression, ROC analysis
- Multivariate logistic regression
- ROC analysis
Main finding
As reported in the abstract
Prevalence of tophus
Odds ratio
2.770
Q2
Odds ratio
5.878
Q3
Odds ratio
7.958
Q4
Observational data: associations, not effects.
Further findings
Spearman correlation of serum FFA with tophus and urine pH
- FFA positively correlated with tophus, negatively with urine pH
- P < 0.001
- FFA had a significant interaction with urine pH on tophus risk
ROC: serum FFA predicting tophus
- Best cut-off value of serum FFA
- 0.46 mmol/L
- Serum FFA had a great discriminant ability to predict tophus
Original publication
Association between serum free fatty acid levels and tophus in patients with gout: a cross‐sectional study. Clin Exp Rheumatol. Published 22 March 2022. doi:10.
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