Distinct uric acid trajectories are associated with incident cardiac conduction block
Authors' conclusion
The moderate-stable and high-stable trajectories are associated with increased risk for new-onset cardiac conduction block.
Study context
- Population
- Kailuan cohort participants, Tangshan, China, free of cardiac conduction block with repeated uric acid (UA) measurements 2006–2012 (mean age 53.12 years)1,405 (2.09%) incident blocks
- Participants
- 67,095 participants
- Exposure
- Moderate-stable and high-stable UA trajectories vs low-stable trajectory
- Outcome
- Incident cardiac conduction block
- Follow-up
- Median 6.19 years
Methodological detailsgroup-based trajectory modeling, Cox proportional hazard regression
- Group-based trajectory modeling
- Cox proportional hazard regression
Main finding
As reported in the abstract
Cardiac conduction block
Each group vs low-stableAdjusted hazard ratio (95% CI)
Moderate-stable
1.30(1.16–1.47)
High-stable
1.86(1.56–2.22)
Observational data: associations, not effects.
Further findings
| Outcome | aHR (95% CI) | |
|---|---|---|
| Atrioventricular blockModerate-stablevs Low-stable | 1.39 (1.12–1.72) | |
| Atrioventricular blockHigh-stablevs Low-stable | 2.90 (2.19–3.83) | |
| Bundle branch blocksModerate-stablevs Low-stable | 1.27 (1.10–1.47) | |
| Bundle branch blocksHigh-stablevs Low-stable | 1.43 (1.13–1.79) | |
| 0.20.5125Adjusted hazard ratio (log scale) |
Original publication
Distinct uric acid trajectories are associated with incident cardiac conduction block. Arthritis Res Ther. Published 27 February 2024. doi:10.
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