Seasonal shifts and population characteristics of uric acid in eastern coastal China: a big data analysis from Hangzhou
Authors' conclusion
Extensive data analysis has uncovered seasonal fluctuations and notable gender- and age-related effects on serum UA concentrations.
Study context
- Population
- Adults (≥18 years) with serum uric acid (UA) data, Hangzhou, eastern coastal China, 2021–2022749,739 serum UA data
- Outcome
- Serum UA reference intervals by season, gender and age (indirect method)
Methodological detailsreal-world big data analysis, indirect method for reference intervals
- Real-world big data analysis
- Indirect method for reference intervals
Main finding
As reported in the abstract
Serum UA reference intervals
- Winter/spring, males 18-44
- 262-539 µmol/L
- Winter/spring, females 18-44
- 175-385 µmol/L
- Winter/spring, males 45+
- 243-525 µmol/L
- Winter/spring, females 45+
- 185-406 µmol/L
- Summer/autumn, males 18-44
- 273-552 µmol/L
- Summer/autumn, females 18-44
- 185-395 µmol/L
- Summer/autumn, males 45+
- 250-537 µmol/L
- Summer/autumn, females 45+
- 192-410 µmol/L
Observational data: associations, not effects.
Further findings
Difference from manufacturer's range (reference change value (RCV))
- Significant difference for males vs manufacturer's range
- No difference for females
Original publication
Seasonal shifts and population characteristics of uric acid in eastern coastal China: a big data analysis from Hangzhou. Clin Exp Rheumatol. Published 1 February 2025. doi:10.
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