Gout & crystal arthritis

Systematic literature review on Calcium Pyrophosphate Deposition (CPPD) nomenclature: condition elements and clinical states— A Gout, Hyperuricaemia and Crystal-Associated Disease Network (G-CAN) consensus project

RMD OpenPublished Systematic literature review

Authors' conclusion

Those results demonstrate the heterogeneity of labels used to describe CPPD condition concepts, with wide variation in condition labels in the medical literature.

Study context

Population
Medical literature on CPPD, 2000–2022articles included of 2375 identified
Participants
886 participants
Outcome
Frequency of labels used for CPPD concepts (pathogenic conditions and crystals, imaging condition elements, asymptomatic and symptomatic condition states)
Methodological detailsG-CAN consensus project, PubMed, Cochrane and Embase, 2000–2022, English language, human studies, eight independent reviewers, a priori list of concepts
  • G-CAN consensus project
  • PubMed, Cochrane and Embase, 2000–2022
  • English language, human studies
  • Eight independent reviewers, a priori list of concepts

Recommendations

As reported in the abstract

Most common labels for the pathogenic condition

'pseudogout'

365 of 783

46.6%

'chondrocalcinosis'

207 of 783

26.4%

'calcium pyrophosphate deposition disease'

181 of 783

23.1%

Most common abbreviation 'CPPD', with different meanings

312 of 390

80.0%

Further findings

Article types among included articles

Case reports
394 (44.5%)
Scoping reviews
169 (19.0%)

Original publication

Systematic literature review on Calcium Pyrophosphate Deposition (CPPD) nomenclature: condition elements and clinical states— A Gout, Hyperuricaemia and Crystal-Associated Disease Network (G-CAN) consensus project. RMD Open. Published 30 January 2025. doi:10.1136/rmdopen-2024-004847

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