Calcium pyrophosphate deposition is associated with an increased risk for nephrolithiasis: A cohort study
Main finding · Prevalence of nephrolithiasisResult — go to the resultAdjusted odds ratio 1.659 95 % CI 1.560–1.764Authors' conclusion
These data suggest that CPPD is an independent risk factor for kidney stone formation and provide further support for the hypothesis that CPPD is a systemic disorder of mineralization with extra-articular implications.
Study context
- Population
- Veterans with CPPD and matched controls (average age 68.5 years; 94.3 % male)
- Participants
- 93,804 veterans
- Exposure
- CPPD vs matched controls
- CPPDn = 18,761
- Controlsn = 75,043reference
- Outcome
- Prevalence of nephrolithiasis
Methodological detailsage-, sex- and date-matched (up to 4 controls), National VA Corporate Data Warehouse
- Age-, sex- and date-matched (up to 4 controls)
- National VA Corporate Data Warehouse
Main finding
As reported in the abstract
Adjusted odds ratio
1.659
95 % CI 1.560–1.764
By group
CPPDvs Controls
adjusted OR 1.659 (95 % CI 1.560–1.764)
Observational data: associations, not effects.
Original publication
Calcium pyrophosphate deposition is associated with an increased risk for nephrolithiasis: A cohort study. Semin Arthritis Rheum. Published 29 January 2025. doi:10.
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