Cardiovascular Disease Risk in Calcium Pyrophosphate Deposition Disease: A Nationwide Study of Veterans
Main finding · MACEResult — go to the resultHazard ratio 0.98 95% CI 0.94–1.02Authors' conclusion
CPPD did not confer an increased risk for MACE, a composite end point including all-cause mortality.
Study context
- Population
- Veterans Health Administration Corporate Data Warehouse, 2010–2014; excluded patients with a cardiovascular event in the 365 days before index (96% male, mean age 78 years, 75% White)>250,000 person-years
- Participants
- 23,124 vs 86,629
- Exposure
- CPPD vs matched patients without CPPD
- CPPDn = 23,124
- Non-CPPDn = 86,629reference
- Outcome
- MACE:
- MI
- Acute coronary syndrome
- Coronary revascularization
- Stroke
- Death
Methodological detailsmatched cohort, age- and sex-matched (≈1:4), Cox proportional hazards models, fully adjusted, nationwide
- Matched cohort
- Age- and sex-matched (≈1:4)
- Cox proportional hazards models, fully adjusted
- Nationwide
Main finding
MACE
Hazard ratio
0.98
95% CI 0.94–1.02
CPPDvs Non-CPPD
HR 0.98 (95% CI 0.94–1.02)
As reported in the abstract
Observational data: associations, not effects.
Secondary outcomes
MACE components: MI, acute coronary syndrome, stroke
- Risks of MI, acute coronary syndrome and stroke significantly higher in CPPD vs non-CPPD
Original publication
Cardiovascular Disease Risk in Calcium Pyrophosphate Deposition Disease: A Nationwide Study of Veterans. Arthritis Care Res (Hoboken). Published 11 October 2022. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →