Profiling of serum oxylipins identifies distinct spectrums and potential biomarkers in young people with very early onset gout
Authors' conclusion
Young men with very early onset gout have distinct oxylipin spectrums, especially those derived from arachidonic acid, eicosapentaenoic acid and docosahexaenoic acid.
Study context
- Population
- Men aged <20 yearsall men aged <20 years
- Participants
- 90 men
- Exposure
- Very early onset gout vs asymptomatic hyperuricaemia vs normouricaemia
- Goutn = 30
- HUn = 30reference
- NUn = 30reference
- Outcome
- Serum oxylipin profile
Methodological detailsdiscovery and validation sample sets, OPLS-DA
- Discovery and validation sample sets
- OPLS-DA
Main finding
As reported in the abstract
- Differential oxylipins, gout vs HU (discovery)
- 21
- Differential oxylipins, gout vs NU (discovery)
- 14
- Down-regulated oxylipins validated, gout vs HU
- Seven
- Down-regulated oxylipins validated, gout vs NU
- five
- AUC of 14(S)-HDHA alone, both comparisons
- 1 (95% CI, 1, 1)
Observational data: associations, not effects.
Original publication
Profiling of serum oxylipins identifies distinct spectrums and potential biomarkers in young people with very early onset gout. Rheumatology (Oxford). Published 16 September 2022. doi:10.
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