Confirming Prior and Identifying Novel Correlates of Acute Calcium Pyrophosphate Crystal Arthritis
Authors' conclusion
Using a validated algorithm to identify nearly 1,700 patients with acute CPP crystal arthritis, we confirmed important correlates of this acute manifestation of CPP deposition. This is the first study to report higher odds for acute CPP crystal arthritis among males.
Study context
- Population
- Partners HealthCare electronic health record (EHR) patients; mean ± SD age 73.7 ± 11.8 years, 56.7% female, 80.8% White, 10.3% Black
- Participants
- 1,697 vs 6,503
- Comparison
- Acute CPP crystal arthritis cases vs matched general patient controls
- Casesn = 1,697
- Controlsn = 6,503reference
- Outcome
- Correlates (sex, race, comorbidities, medications) of acute CPP crystal arthritis, fully adjusted odds ratios (ORs)
Methodological detailsmatched on year of first EHR encounter and index date, conditional logistic regression, validated algorithm (PPV 81%)
- Matched on year of first EHR encounter and index date
- Conditional logistic regression
- Validated algorithm (PPV 81%)
Main finding
As reported in the abstract
Correlates of acute CPP crystal arthritis, fully adjusted
- OA, OR
- 3.08
- Male sex, OR
- 1.35
- RA, OR
- 2.09
- Gout, OR
- 2.83
- Proton pump inhibitors, OR
- 1.94
- Loop diuretics, OR
- 1.60
- Thiazides, OR
- 1.46
- Black vs White race, OR (lower odds)
- 0.47
Observational data: associations, not effects.
Original publication
Confirming Prior and Identifying Novel Correlates of Acute Calcium Pyrophosphate Crystal Arthritis. Arthritis Care Res (Hoboken). Published 15 September 2022. doi:10.
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