Systemic inflammation in asymptomatic hyperuricaemia with sonographic crystal deposits, including a comparison with normouricaemia and gout
Authors' conclusion
Hyperuricaemia is associated with substantial inflammation and some degree of active pyroptosis. Four different ultrasound definitions for AH with MSU deposits yielded similar findings, although we noted some differences in calprotectin, CRP, and TGF-β. Sex, obesity, and comorbidities influenced some inflammatory responses.
Study context
- Population
- Participants grouped by serum urate levels, musculoskeletal US and history of flares
- Participants
- 122 participants
- Exposure
- Asymptomatic hyperuricaemia (AH) with sonographic monosodium urate (MSU) deposits vs AH without deposits, intercritical gout and normouricaemia
- Outcome
- Inflammatory profile: serum acute phase reactants, cytokines, pyroptosis derivates and neutrophil-related proteins
Methodological detailsfour ultrasound definitions of MSU deposition tested, linear regression model
- Four ultrasound definitions of MSU deposition tested
- Linear regression model
Main finding
As reported in the abstract
Inflammatory markers
Rates of MSU deposition in AH, depending on the definition used
26.0% to 68.8%
Observational data: associations, not effects.
Original publication
Systemic inflammation in asymptomatic hyperuricaemia with sonographic crystal deposits, including a comparison with normouricaemia and gout. Rheumatology (Oxford). Published 30 September 2024. doi:10.
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