Prevalence of crystal deposits in asymptomatic hyperuricemia according to different scanning definitions: A comparative study
Authors' conclusion
Rates of sonographic deposition in AH varied dramatically among studied protocols, while some could discriminate accompanying inflammation, all highlighting the need for a validated, consensus-based definition.
Study context
- Population
- Patients with asymptomatic hyperuricemia (serum urate ≥7 mg/dL) undergoing musculoskeletal US of 10 locations for OMERACT elementary gout lesions
- Participants
- 77 patients
- Exposure
- Different sonographic definitions of asymptomatic hyperuricemia (AH) with crystal deposits
- Outcome
- Crystal deposit rates according to different scanning definitions
Methodological detailscomparative study of ultrasound definitions
- Comparative study of ultrasound definitions
Main finding
As reported in the abstract
Crystal deposition rate across definitions
- Lowest deposition rate (>1 location with grade 2-3 DC or tophi)
- 23.4%
- Highest deposition rate (any deposit in all 10 locations)
- 87.0%
- Locations with tophi, median (IQR 0-2)
- 1
- Locations with aggregates, median (IQR 1-2)
- 1
- Locations with DC sign, median (IQR 0-1)
- 0
Observational data: associations, not effects.
Further findings
Accompanying inflammation (positive power-Doppler (PD) signal) and erosions
- Positive PD signal
- 19.5%
- Erosions
- 28.4%
- Positive PD signal better discriminated by criteria requiring grade 2-3 or >1 location with lesions
- Erosions and clinical and laboratory variables similar among protocols
Original publication
Prevalence of crystal deposits in asymptomatic hyperuricemia according to different scanning definitions: A comparative study. Semin Arthritis Rheum. Published 20 June 2024. doi:10.
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