Worldwide trends in hyperuricaemia from 2000 to 2023: a systematic review and modelling analysis
Authors' conclusion
The global prevalence and prevalent cases of hyperuricaemia have risen markedly over the past two decades in both men and women, driven by population growth, ageing, and increasing age-specific rates.
Study context
- Population
- Adults in population-based studies reporting hyperuricaemia prevalence; estimates for 200 countries and territories, 2000–2023402 reports (420 studies), 34 countries
- Participants
- 7,488,451 adults
- Comparison
- Women vs Men
- Outcome
- Sex-specific global, regional and national hyperuricaemia prevalence and cases
- Follow-up
- 2000 to 2023
Methodological detailsBayesian hierarchical metaregression, population-based studies, no language restrictions, No individuals with lived experience of hyperuricaemia were involved in study design or conduct
- Bayesian hierarchical metaregression
- Population-based studies
- No language restrictions
- No individuals with lived experience of hyperuricaemia were involved in study design or conduct
Pooled result
As reported in the abstract
Global hyperuricaemia prevalence, 2000 to 2023
| Group | Value | 2000 prevalence |
|---|---|---|
| Women | 11.2% (95% CrI 8.2–15.2) | 6.7% (95% CrI 5.0-9.5) |
| Men | 18.6% (95% CrI 14.6–25.1) | 12.3% (9.8-17.0) |
Value
Women11.2% (95% CrI 8.2–15.2)
Men18.6% (95% CrI 14.6–25.1)
2000 prevalence
Women6.7% (95% CrI 5.0-9.5)
Men12.3% (9.8-17.0)
Further pooled results
Largest regional absolute increase in prevalence · 2000 to 2023
Region Women Polynesia and Micronesia · Men East Asia
| Outcome | Women | Men |
|---|---|---|
| Global prevalent cases, 2000 to 2023 | ||
| 2000 cases | 126 million (95% CrI 93-178) | 226 million (180-312) |
| South Asia prevalent cases (highest number), 2023 | 102 million events | 120 million events |
Global prevalent cases, 2000 to 2023
- Population growth and ageing explained roughly half the increase
Regional prevalence range, 2023
- Women: North Africa and the Middle East (lowest)
- 4.0% (95% CrI 2.8-5.9)
- Women: Polynesia and Micronesia (highest)
- 42.6% (17.3-61.9)
- Men: central Asia (lowest)
- 7.5% (4.9-11.2)
- Men: Polynesia and Micronesia (highest)
- 36.5% (12.0-66.8)
Country-level prevalence range, 2023
- Women: Yemen (lowest)
- 1.4% (95% CrI 1.0-2.1)
- Women: Cook Islands (highest)
- 55.8% (22.6-75.8)
- Men: Yemen (lowest)
- 3.7% (2.3-5.9)
- Men: Cook Islands (highest)
- 46.5% (14.2-78.6)
- Countries and territories with increased prevalence, women
- 199
- Countries and territories with increased prevalence, men
- 195
Prevalence by setting and age
- Consistently higher in high-income and urban settings; increased with age in both sexes, with sex differences narrowing in older age groups
Original publication
Worldwide trends in hyperuricaemia from 2000 to 2023: a systematic review and modelling analysis. Lancet Rheumatol. Published 6 February 2026. doi:10.
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