Relation of Colchicine to Total Joint Arthroplasty Among People With Gout in a Population‐Based Cohort Study
Main finding · TJAResult — go to the resultHazard ratio 0.88 95% CI 0.81–0.96Authors' conclusion
In this large population-based cohort of people with gout, colchicine initiation was associated with a modestly lower risk of TJA.
Study context
- Population
- Participants with gout, UK primary care database (2000–2021); mean age 60 years, mean BMI 30median follow-up 4.5 years
- Exposure
- Colchicine initiators vs propensity score matched noninitiators
- Colchicine initiatorsn = 31,478
- Outcome
- Risk of total joint arthroplasty (TJA)
Methodological detailsnew-user design, time-stratified, propensity score matched, Cox proportional hazard regression
- New-user design
- Time-stratified
- Propensity score matched
- Cox proportional hazard regression
Main finding
TJA
Hazard ratio
0.88
95% CI 0.81–0.96
Colchicine initiatorsvs Noninitiators
HR 0.88 (95% CI 0.81–0.96)
As reported in the abstract
Observational data: associations, not effects.
Further findings
| Outcome | HR (95% CI) | |
|---|---|---|
| TJA in participants with gout and knee/hip OA (subgroup) | 0.77 (0.64–0.92) | |
| 0.512Hazard ratio (log scale) |
Total joint arthroplasty (TJA) in participants with gout and knee/hip osteoarthritis (OA) (subgroup)
- 23% lower risk of TJA
Original publication
Relation of Colchicine to Total Joint Arthroplasty Among People With Gout in a Population‐Based Cohort Study. Arthritis Rheumatol. Published 6 February 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →