Genetic risk, lifestyle adherence, and risk of developing hyperuricaemia in a Japanese population
Main finding · Incident hyperuricaemiaResult — go to the resultOdds ratio 5.34 95% CI 2.61–12.10Authors' conclusion
A healthy lifestyle to prevent hyperuricaemia, irrespective of genetic risk, may mitigate the genetic risk.
Study context
- Population
- Hyperuricaemia-free individuals aged ≥20 years, Tohoku Medical Megabank Community-based cohort study, Japan (80.7% females; mean age 57.7 years)
- Participants
- 7,241 individuals
- Exposure
- Genetic risk and healthy-lifestyle adherence categories
- Outcome
- Incident hyperuricaemia (uric acid ≥7.0 mg/dL or self-reported history of hyperuricaemia)
- Follow-up
- 3.5 years
Methodological detailscommunity-based cohort, multiple logistic regression
- Community-based cohort
- Multiple logistic regression
Main finding
Incident hyperuricaemia
Odds ratio
5.34
95% CI 2.61–12.10
High genetic risk and poor lifestyle
OR 5.34 (95% CI 2.61–12.10)
As reported in the abstract
- Hyperuricaemia developed (whole cohort)
- 217 (3.0%)
Observational data: associations, not effects.
Further findings
| Outcome | Lifestyle | Lifestyle and PRS | P value |
|---|---|---|---|
| Predictive ability (AUROC)Not statistically significant | P = 0.07 | ||
| AUROC | 0.771 (95% CI 0.736-0.806) | 0.785 (95% CI 0.751-0.819) |
Original publication
Genetic risk, lifestyle adherence, and risk of developing hyperuricaemia in a Japanese population. Rheumatology (Oxford). Published 13 September 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →