Serum Uric Acid Levels in Older Adults: Associations With Clinical Outcomes and Implications for Reference Intervals in Those Aged 70 Years and Over
Authors' conclusion
Although previous reports have linked abnormal SUA levels to adverse health outcomes, our findings show no associations within the reference range, except for an increased fracture risk among women with low SUA levels.
Study context
- Population
- Relatively healthy, community-dwelling individuals aged ≥70 years in Australia (median age 74 years)reference sample nested in study sample
- Participants
- 11,446 vs 10,501
- Exposure
- Study sample vs Reference sample
- Study samplen = 11,446
- Reference samplen = 10,501
- Outcome
- SUA reference interval (2.5th and 97.5th percentile), stratified by sex
Methodological detailssecondary analysis of the ASPirin in Reducing Events in the Elderly (ASPREE) trial, community-dwelling, Cox proportional hazard models, sex-stratified reference intervals
- Secondary analysis of the ASPREE trial
- Community-dwelling
- Cox proportional hazard models
- Sex-stratified reference intervals
Main finding
As reported in the abstract
SUA reference interval (2.5th–97.5th percentile)
Men
0.24 to 0.54 mmol/L
Women
0.19 to 0.48 mmol/L
Observational data: associations, not effects.
Further findings
All-cause mortality, disability-free survival, CVD, MACE, cancer incidence and mortality, dementia
- No association with serum uric acid (SUA) levels in either the study or reference samples, after adjustment for potential confounders
Fractures with low SUA levels (women)
- HR
- 1.23
- 95% CI
- 1.04-1.46
Original publication
Serum Uric Acid Levels in Older Adults: Associations With Clinical Outcomes and Implications for Reference Intervals in Those Aged 70 Years and Over. Arthritis Care Res (Hoboken). Published 17 December 2025. doi:10.
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