Weight Loss for Patients With Gout and Concomitant Obesity: A Proof‐of‐Concept Randomized Trial
Primary result · Change in body weightResult — go to the resultDifference −7.7 kg 95% CI −10.7 to −4.7Authors' conclusion
An intensive dietary intervention was safe and effectively lowered body weight in people with obesity and gout, but the weight loss did not directly translate into effects on SU level, fatigue, and pain.
Study context
- Population
- Individuals with obesity and gout, Denmark (mean age 60.3 years; mean BMI 35.6; 97% men)ITT population
- Participants
- 61 individuals
- Comparison
- Low-energy diet vs control diet
- Low-energy dietn = 29
- Control dietn = 32reference
- Primary endpoint
- Change in body weight
- Follow-up
- 16 weeks
Methodological detailsnonmasked, parallel-group, proof-of-concept, Enrolment between December 1, 2018, and June 1, 2019
- Nonmasked
- Parallel-group
- Proof-of-concept
- Enrolment between December 1, 2018, and June 1, 2019
Primary result
As reported in the abstract
Difference
−7.7 kg
95% CI −10.7 to −4.7
P < 0.001
Change by group
Low-energy diet
−15.4
kg
Control diet
−7.7
kg
Low-energy dietvs Control diet
difference −7.7 kg (95% CI −10.7 to −4.7); P < 0.001
Secondary outcomes
Change in serum urate (SU) level and fatigue (key secondary) · 16 weeks
- Differences between groups could not be confirmed, despite results potentially in favour of low-energy diet
Pain (key secondary) and gout flares · 16 weeks
- No differences observed between groups
Safety
Serious adverse events and deaths
- None occurred during the trial
Original publication
Weight Loss for Patients With Gout and Concomitant Obesity: A Proof‐of‐Concept Randomized Trial. Arthritis Rheumatol. Published 20 February 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →