Unclosing Premature Mortality Gap Among Patients With Gout in the US General Population, Independent of Serum Urate and Atherosclerotic Cardiovascular Risk Factors
Authors' conclusion
Patients with gout experience a persistent mortality gap in all-cause and CV deaths, even adjusting for SU and ASCVD risk factors, supporting a role for gout-specific pathways (eg, flare inflammation).
Study context
- Population
- US general population, early (1988–1994 baseline) and late (2007–2016 baseline) cohorts; replication in a nationwide UK cohort (2006–2010 baseline)
- Exposure
- Prevalent gout vs no gout
- Outcome
- All-cause mortality
Methodological detailsserial US nationwide prospective cohorts, UK nationwide replication cohort
- Serial US nationwide prospective cohorts
- UK nationwide replication cohort
Main finding
As reported in the abstract
All-cause mortality, adjusted
Gout vs No goutAdjusted hazard ratio (CI)
Early US cohort
1.20(1.03–1.40)
Late US cohort
1.19(1.04–1.37)
Observational data: associations, not effects.
Further findings
| Outcome | aHR (CI) | |
|---|---|---|
| All-cause mortality, further adjusted for SUGoutvs No goutEarly US cohort | 1.19 (1.02–1.38) | |
| All-cause mortality, further adjusted for SUGoutvs No goutLate US cohort | 1.19 (1.03–1.37) | |
| All-cause mortality, UK late cohort | 1.61 (1.47–1.75) | |
| CV mortality, late US cohort | 1.39 (1.09–1.78) | |
| Circulatory, CV and coronary heart disease deaths, UK incident goutGoutvs No goutCirculatory deaths | 1.48 (1.24–1.76) | |
| Circulatory, CV and coronary heart disease deaths, UK incident goutGoutvs No goutCV deaths | 1.49 (1.20–1.85) | |
| Circulatory, CV and coronary heart disease deaths, UK incident goutGoutvs No goutCoronary heart disease deaths | 1.59 (1.26–1.99) | |
| 0.512Adjusted hazard ratio (log scale) |
- All-cause mortality, UK late cohort — Associations larger among women
- P = 0.04
All-cause mortality, UK late cohort
- Associations prominent among Black individuals
Original publication
Unclosing Premature Mortality Gap Among Patients With Gout in the US General Population, Independent of Serum Urate and Atherosclerotic Cardiovascular Risk Factors. Arthritis Care Res (Hoboken). Published 14 February 2024. doi:10.
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