Major cardiovascular events in patients with cardiovascular monosodium urate deposits in atherosclerotic plaques
Main finding · Major adverse cardiac eventsResult — go to the resultOdds ratio 2.4Authors' conclusion
This is the first study demonstrating the higher hazard of major adverse cardiac events in patients with dual energy computed tomography-verified cardiovascular monosodium urate deposits.
Study context
- Population
- Patients with clinical suspicion of gout who underwent dual energy CT of the affected limb and thorax, 1 June 2012 to 5 December 2019 (gout, hyperuricemia and controls)131 gout, 40 hyperuricemia, 18 controls
- Participants
- 189 patients
- Exposure
- Cardiovascular MSU deposits vs no cardiovascular MSU deposits on dual energy CT
- Cardiovascular monosodium urate depositsn = 85
- Without cardiovascular monosodium urate depositsn = 104reference
- Outcome
- Major adverse cardiac events
- Follow-up
- Median 33 months (range 0-108 months)
Main finding
As reported in the abstract
Odds ratio
2.4
P = 0.018
Events by group
Observational data: associations, not effects.
Further findings
Serum acute phase reactants, uric acid levels and CT calcium scores
- Increased in patients with cardiovascular MSU deposits vs without
Original publication
Major cardiovascular events in patients with cardiovascular monosodium urate deposits in atherosclerotic plaques. Rheumatology (Oxford). Published 23 April 2024. doi:10.
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