Do Monosodium Urate Crystals Reduce at Different Rates in Joints and Tendons During Urate-Lowering Therapy? A Dual-Energy Computed Tomography Study
Main finding · Change in dual-energy CT urate volumeResult — go to the resultLeast means difference 0.02 cm³ 95% CI −0.09 to 0.13Authors' conclusion
This DECT study indicates that similar rates of MSU crystal dissolution occur at both joints and tendons during oral ULT.
Study context
- Population
- Participants with gout from 2 trials of oral ULT; total urate volume ≥ 0.5 cm³ on first dual-energy CT, reduced on second, deposition in ≥1 joint and ≥1 tendondeposits from 50 participants
- Participants
- 125 vs 95
- Comparison
- Change in dual-energy CT urate volume of joint deposits vs tendon deposits during oral ULT
- Joint depositsn = 125
- Tendon depositsn = 95reference
- Outcome
- Change in dual-energy CT urate volume of joint vs tendon deposits
- Follow-up
- Year 1
Methodological detailspaired dual-energy CT scans of the feet and ankles, general linear mixed analysis of covariance
- Paired dual-energy CT scans of the feet and ankles
- General linear mixed analysis of covariance
Main finding
Change in dual-energy CT urate volume
Least means difference
0.02 cm³
95% CI −0.09 to 0.13
P = 0.73
Change by group
Joint deposits
−0.37
least means change · 95% CI −0.47–-0.26 · cm³
Tendon deposits
−0.39
least means change · 95% CI −0.50–-0.27 · cm³
Joint depositsvs Tendon deposits
least means difference 0.02 cm³ (95% CI −0.09 to 0.13); P = 0.73
As reported in the abstract
Original publication
Do Monosodium Urate Crystals Reduce at Different Rates in Joints and Tendons During Urate-Lowering Therapy? A Dual-Energy Computed Tomography Study. J Rheumatol. Published 1 October 2025. doi:10.
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