Relationship between serum urate and changes in dual-energy CT monosodium urate crystal volume over 1 year in people with gout: an individual participant data analysis
Authors' conclusion
Over 1 year, MSU crystal dissolution, as measured by DECT, occurs with mean serum urate bands of<0.24 mmol/L and 0.24-0.29 mmol/L while MSU crystal formation occurs with mean serum urate≥0.48 mmol/L.
Study context
- Population
- People with gout with serial dual-energy CT (DECT) scans of both feet over a 12-month epoch of stable urate-lowering therapy and serum urate concentrations
- Participants
- 251 people3 studies
- Comparison
- Mean serum urate cut-points and bands vs change in DECT urate volume over 12 months
- Outcome
- Change in DECT urate volume by mean serum urate cut-point and band
- Follow-up
- 12 months
Methodological detailsthree studies pooled, mixed models analysis of covariance
- Three studies pooled
- Mixed models analysis of covariance
Main finding
As reported in the abstract
Change in DECT urate volume by mean serum urate · 1 year
- Difference in change in DECT volume, 0.42 mmol/L cut-point
- p=0.0044
- Difference in change in DECT volume, 0.48 mmol/L cut-point
- p<0.0001
Original publication
Relationship between serum urate and changes in dual-energy CT monosodium urate crystal volume over 1 year in people with gout: an individual participant data analysis. Ann Rheum Dis. Published 2 January 2025. doi:10.
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