Gout and incidence of 12 cardiovascular diseases: a case–control study including 152 663 individuals with gout and 709 981 matched controls
Main finding · Cardiovascular diseaseResult — go to the resultHazard ratio 1.58 95% CI 1.52–1.63Authors' conclusion
Patients with gout had an excess risk of developing a broad range of cardiovascular diseases that extend beyond atherosclerotic diseases and include heart failure, arrhythmias, valve disease, and thromboembolic diseases. Excess risk was highest in women and younger individuals.
Study context
- Population
- Individuals with first-time gout aged 80 years or younger and free of CVD, and matched controls, UK Clinical Practice Research Datalink, 2000–2017, followed up until June 30, 2019median follow-up 6.5 years
- Participants
- 152,663 vs 709,981
- Comparison
- Gout vs matched controls without gout
- Goutn = 152,663
- Matched controlsn = 709,981reference
- Outcome
- Incidence of 12 cardiovascular diseases
Methodological detailsup to five controls per patient matched on age, sex, socioeconomic status, geographical region and calendar time, linked primary and secondary electronic health records (UK CPRD), Cox proportional hazards models
- Up to five controls per patient matched on age, sex, socioeconomic status, geographical region and calendar time
- Linked primary and secondary electronic health records (UK CPRD)
- Cox proportional hazards models
Main finding
Cardiovascular disease · median follow-up 6.5 years (IQR 3.1-10.5)
Hazard ratio
1.58
95% CI 1.52–1.63
Events by group
Goutvs Matched controls
HR 1.58 (95% CI 1.52–1.63)
As reported in the abstract
Further findings
| Outcome | Estimate | |
|---|---|---|
| CVD by sex (subgroups)Goutvs Matched controlsWomen | HR 1.88 (CI 1.75–2.02) | |
| CVD by sex (subgroups)Goutvs Matched controlsMen | HR 1.49 (CI 1.43–1.56) | |
| CVD in people aged <45 years (subgroup)Highest among all age groups | HR 2.22 (CI 1.92–2.57) | |
| CVD adjusted for known cardiovascular risk factorsAttenuated but did not eliminate the excess risk | aHR 1.31 (CI 1.27–1.36) | |
| 0.20.5125Ratio (log scale) |
| Outcome | Mean difference (kg/m²) (95% CI) | |
|---|---|---|
| BMI | 2.90 (2.87–2.93) | |
| −2024Difference, kg/m² (linear scale) |
BMI
- Higher prevalence of CKD, dyslipidaemia, history of hypertension, obesity and type 2 diabetes in gout
Original publication
Gout and incidence of 12 cardiovascular diseases: a case–control study including 152 663 individuals with gout and 709 981 matched controls. Lancet Rheumatol. Published March 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →