Interactions Between Genetic Risk and Diet Influencing Risk of Incident Female Gout: Discovery and Replication Analysis of Four Prospective Cohorts
Authors' conclusion
The deleterious effect of genetic predisposition on risk of incident female gout was more pronounced among women with unhealthy diets, with nearly half the excess risk attributable to this gene-diet interaction.
Study context
- Population
- Women from Nurses' Health Study (NHS) (discovery) and 3 additional prospective female cohorts from the US and UK (replication)18,244 discovery
- Exposure
- Healthy vs unhealthy DASH score, by higher vs lower urate genetic risk score (GRS)
- Outcome
- Incident female gout
Methodological detailsgene-diet interaction analysis, discovery and replication, four prospective cohorts, multivariable RR
- Gene-diet interaction analysis
- Discovery and replication
- Four prospective cohorts
- Multivariable RR
Main finding
As reported in the abstract
Incident gout, healthy vs unhealthy DASH by GRS stratum (all cohorts combined)
Multivariable relative risk (95% CI)P value
Healthy DASHvs Unhealthy DASHamong higher GRS
0.67(0.60–0.76)
P = 0.001for multiplicative interactionHealthy DASHvs Unhealthy DASHamong lower GRS
0.91(0.78–1.05)
P = 0.001for multiplicative interactionHigher GRSvs Lower GRSamong unhealthy DASH
2.03(1.80–2.29)
Higher GRSvs Lower GRSamong healthy DASH
1.50(1.31–1.71)
Observational data: associations, not effects.
Further findings
- Additive interaction significant in both discovery and replication cohorts
- P < 0.001
- Excess risk attributable to additive gene-diet interaction (all cohorts combined)
- 51%
Original publication
Interactions Between Genetic Risk and Diet Influencing Risk of Incident Female Gout: Discovery and Replication Analysis of Four Prospective Cohorts. Arthritis Rheumatol. Published 21 March 2023. doi:10.
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