Adherence to Healthy and Unhealthy Plant-Based Diets and the Risk of Gout
Authors' conclusion
The findings of this prospective cohort study of PDIs and gout support current dietary recommendations to increase consumption of healthy plant foods while lowering intake of unhealthy plant foods to mitigate gout risk.
Study context
- Population
- US men (Health Professionals Follow-Up Study) and women (Nurses' Health Study) free of gout at baseline2,709 incident gout cases
- Participants
- 122,679 men
- Exposure
- Highest (Q5) vs lowest (Q1) quintile of adherence to overall (PDI), healthy (hPDI) and unhealthy (uPDI) plant-based diet indices
- Outcome
- Incident gout confirmed by supplementary questionnaire to meet preliminary ACR survey criteria
Methodological detailspopulation-based cohorts (HPFS 1986-2012, NHS 1984-2010), multivariable-adjusted Cox proportional hazards regression, quintiles of adherence
- Population-based cohorts (HPFS 1986-2012, NHS 1984-2010)
- Multivariable-adjusted Cox proportional hazards regression
- Quintiles of adherence
Main finding
As reported in the abstract
Incident gout by PDI, hPDI and uPDI (pooled)
Estimate (95% CI)P value
Q5vs Q1
pooled HR (overall PDI) 1.02(0.89–1.17)
P = 0.63for trendQ5vs Q1
HR (hPDI, pooled) 0.79(0.69–0.91)
P = 0.002for trendQ5vs Q1
HR (uPDI, pooled) 1.17(1.03–1.33)
P = 0.02for trendObservational data: associations, not effects.
Further findings
| Outcome | HR (95% CI) | P value | |
|---|---|---|---|
| Incident gout by uPDI in women (subgroup)Q5vs Q1 | 1.31 (1.05–1.62) | P for trend = 0.01 | |
| 0.512Hazard ratio (log scale) |
Incident gout per 1 serving/d of individual food groups (pooled HR)
- Whole grains: HR
- 0.93 (95% CI 0.89-0.97)
- Tea and coffee: HR
- 0.95 (95% CI 0.92-0.97)
- Dairy: HR
- 0.86 (95% CI 0.82-0.90)
- Fruit juice: HR
- 1.06 (95% CI 1.00-1.13)
- Sugar-sweetened beverages: HR
- 1.16 (95% CI 1.07-1.26)
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Adherence to Healthy and Unhealthy Plant-Based Diets and the Risk of Gout. JAMA Netw Open. Published 1 May 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →