Provision of knee bracing for knee osteoarthritis (PROP OA): multicentre, parallel group, superiority, statistician blinded, randomised controlled trial
Primary result · KOOS-5 improvementResult — go to the resultAdjusted mean difference 3.39 95% CI 0.96–5.82Authors' conclusion
Adding compartment specific knee bracing and an adherence intervention to advice, written information, and exercise instruction resulted in small improvements in patient reported outcomes among individuals with knee osteoarthritis.
Study context
- Population
- Adults aged ≥45 years with symptoms of knee OA, recruited through general practices and the community in Cheshire, Manchester, North Tyneside and Staffordshire, England; enrolment 25 November 2019 to 16 September 2022394 (85%) analysable at 6 months
- Participants
- 466 adults
- Comparison
- Compartment-specific knee bracing with adherence intervention plus advice, written information and exercise instruction (AIE+B) vs AIE only
- Primary endpoint
- Composite patient-reported KOOS-5 (0-100)
- Follow-up
- Six months after randomisation
Methodological detailsmulticentre, parallel group, superiority, statistician blinded, randomised 1:1; block; stratified; centralised web based
- Multicentre
- Parallel group
- Superiority
- Statistician blinded
- Randomised 1:1; block; stratified; centralised web based
Primary result
KOOS-5 improvement · six months
Adjusted mean difference
3.39
95% CI 0.96–5.82
AIE+Bvs AIE
adjusted mean difference 3.39 (95% CI 0.96–5.82)
As reported in the abstract
Secondary outcomes
Knee Osteoarthritis Outcomes Score (KOOS) pain (0-100), benefit of AIE+B over AIE · six months
- Secondary outcomes showed benefits of AIE+B over AIE that diminished over time
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Provision of knee bracing for knee osteoarthritis (PROP OA): multicentre, parallel group, superiority, statistician blinded, randomised controlled trial. BMJ. Published 26 January 2026. doi:10.
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