Insights into knee post-traumatic osteoarthritis pathophysiology from the relationship of serum biomarkers to radiographic features in the ADVANCE cohort
Authors' conclusion
This large, unique study suggests different pathological processes underpinning each radiographic feature of PTOA, including predominant unbalanced ECM-catabolism and inflammation contributing to JSN, ECM-catabolism and increased inflammation contributing to osteophyte development and an inflammation-predominant process contributing to subchondral sclerosis.
Study context
- Population
- Young, male, severely injured British servicepersonnel in the ADVANCE cohort, serum and radiographs at 8 and 11 years post-injury872 analysed
- Participants
- 1,145 participants
- Outcome
- Association (cross-sectional) and prediction (longitudinal) of serum biomarkers with radiographic post-traumatic osteoarthritis (PTOA) features (JSN, osteophytes, sclerosis)
Methodological detailscross-sectional and longitudinal analyses, LASSO predictor selection
- Cross-sectional and longitudinal analyses
- LASSO predictor selection
Main finding
As reported in the abstract
Higher leptin concentrations in those with joint space narrowing (JSN) (FDR-corrected q-value)
q = 0.04
COMP area under a ROC curve (AUROC) for new JSN
0.604
0.543,0.664
COMP, IL-1β and leptin AUROC for new osteophytes
0.586
0.524,0.646
TNF-α, IL-1β and adiponectin AUROC for new sclerosis
0.590
0.520,0.659
Observational data: associations, not effects.
Original publication
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