Association of serum biomarkers with radiographic knee osteoarthritis, knee pain and function in a young, male, trauma-exposed population – Findings from the ADVANCE study
Authors' conclusion
The most notable findings of this large, unique study are the similarities between those with rOA regardless of trauma-exposure, the injury-pattern and traumatic-amputation-associated differences in COMP, and the relationship between adipokines and pain.
Study context
- Population
- Young male UK combat-injured and uninjured service personnel (ADVANCE study), aged 34.1 ± 5.4, 8.9 ± 2.2 years post-injury or deploymentall male
- Participants
- 1,145 participants
- Exposure
- Combat-injured vs frequency-matched uninjured participants; with vs without radiographic OA (rOA) and knee pain
- Trauma-exposedn = 579
- Matchedn = 566reference
- Outcome
- Differences in serum osteoarthritis (OA) biomarkers between those with/without combat injury, rOA and pain
Methodological detailsfrequency-matched (age, rank, deployment and job-role), adjusted for age, body mass, socioeconomic status, and ethnicity
- Frequency-matched (age, rank, deployment and job-role)
- Adjusted for age, body mass, socioeconomic status, and ethnicity
Main finding
As reported in the abstract
Serum OA biomarkers
- No significant differences between trauma-exposed and unexposed participants with rOA
- Trauma-exposed vs Matched: P = 0.01
- Traumatic-amputation vs non-amputees: P < 0.001
- Knee pain vs No knee pain: P = 0.005
- Knee pain vs No knee pain: P = 0.017
Observational data: associations, not effects.
Original publication
Association of serum biomarkers with radiographic knee osteoarthritis, knee pain and function in a young, male, trauma-exposed population – Findings from the ADVANCE study. Osteoarthritis Cartilage. Published 3 August 2024. doi:10.
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