Infrapatellar fat pad size and subcutaneous fat in knee osteoarthritis radiographic progression: data from the osteoarthritis initiative
Authors' conclusion
Subjects with radiographic progression of KOA, had significant increases in IPFP CSA and subcutaneous adipose tissue while BMI and abdominal circumference remained stable.
Study context
- Population
- Osteoarthritis Initiative (OAI) participants with knee OA
- Participants
- 315 vs 315
- Comparison
- Knees with radiographic OA progression vs matched controls
- Casesn = 315
- Controlsn = 315reference
- Outcome
- Radiographic knee OA progression (increase of ≥ 1 KL)
- Follow-up
- 48 months
Methodological detailsmatched by age, sex, race and baseline KL, conditional logistic regression, mediation analysis
- Matched by age, sex, race and baseline KL
- Conditional logistic regression
- Mediation analysis
Main finding
As reported in the abstract
Radiographic knee OA progression by adipose tissue change · 24-month changes
Adjusted odds ratio (95% CI)
Δ IPFP CSA, per 1 SD increase
9.299(5.357–16.141)
Δ SCATthigh, per 1 SD increase
1.646(1.288–2.103)
Per 1 SD increase, as printed
Observational data: associations, not effects.
Further findings
Mediation of baseline BMI–progression association by ΔIPFP CSA
- Proportion mediated
- 87%
Original publication
Infrapatellar fat pad size and subcutaneous fat in knee osteoarthritis radiographic progression: data from the osteoarthritis initiative. Arthritis Res Ther. Published 30 July 2024. doi:10.
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