High frequency of Basic calcium phosphate (BCP), but less CPP crystal-mediated calcification in cartilage and synovial membrane of osteoarthritis patients
Authors' conclusion
BCP is the predominant crystal type in calcified cartilage and synovium while CPP deposition is rare, often coinciding with BCP.
Study context
- Population
- OA patients undergoing knee replacement surgery; cartilage and synovial membrane samples
- Participants
- 92 patients
- Outcome
- Frequency and distribution of BCP and CPP-based calcification in cartilage and synovial membrane
Methodological detailsconventional radiography, histology and Raman spectroscopy
- Conventional radiography, histology and Raman spectroscopy
Main finding
As reported in the abstract
Crystal type by Raman spectroscopy
BCP crystals in cartilage samples
75%
BCP crystals in synovial samples
43%
CPP deposition in cartilage samples
18%
CPP deposition in synovial samples
15%
Observational data: associations, not effects.
Further findings
Calcifications on conventional radiography
- Patients with calcifications
- 35%
Calcified deposits on Von Kossa staining
- Cartilage samples
- 88%
- Synovial samples
- 57%
Original publication
High frequency of BCP, but less CPP crystal-mediated calcification in cartilage and synovial membrane of osteoarthritis patients. Osteoarthritis Cartilage. Published 11 May 2024. doi:10.
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