Intensive diet or knee arthroplasty for severe knee osteoarthritis: The inka randomised trial
Primary result · Oxford Knee Score (0-48; higher better)Result — go to the resultBetween-group difference −8.2 95% CI −11.5 to −5.0Authors' conclusion
Among people with obesity and severe knee osteoarthritis eligible for knee arthroplasty a 12-week supervised intensive weight loss program was not non-inferior to knee arthroplasty, shown as clinically inferior improvements in patient reported knee pain and function after 6 months.
Study context
- Population
- People with obesity (BMI ≥30 kg/m²) and knee OA eligible for knee arthroplastyrecruitment target of 200 not reached
- Participants
- 92 people
- Comparison
- Intensive dietary weight loss program vs knee arthroplasty
- INn = 45
- Knee arthroplasty (KA)n = 47reference
- Primary endpoint
- Knee pain and function by Oxford Knee Score (0-48; higher better); non-inferiority margin 4 points
- Follow-up
- 6 months after treatment start
Methodological detailsnon-inferiority, comparative effectiveness, 12-week wait list after randomisation
- Non-inferiority
- Comparative effectiveness
- 12-week wait list after randomisation
Primary result
Oxford Knee Score (0-48; higher better)
Between-group difference
−8.2
95% CI −11.5 to −5.0
By group
IN
28.2
KA
36.5
INvs KA
between-group difference −8.2 (95% CI −11.5 to −5.0)
As reported in the abstract
Secondary outcomes
| Outcome | IN | KA |
|---|---|---|
| Change in body weightMean, kg | −11.0 | −1.3 |
| Percent change | −10.4% | −1.2% |
Safety
- Adverse event incidence similar in the two groups
Original publication
Intensive diet or knee arthroplasty for severe knee osteoarthritis: The inka randomised trial. Osteoarthritis Cartilage. Published 10 July 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →