Patients with knee osteoarthritis exhibit an abnormal three-dimensional lower limb phenotype: An EOS imaging study
Authors' conclusion
Together, these findings reveal a focused multiplanar, weight-bearing lower-limb phenotype in KOA patients
Study context
- Population
- Weight-bearing EOS images from a single-centre database; patients with knee OA and matched controls
- Participants
- 558 participants279 knee osteoarthritis (KOA)-control pairs
- Exposure
- Knee OA vs matched controls
- KOAn = 279
- Controlsn = 279reference
- Outcome
- Weight-bearing 3D lower-limb phenotype: 17 pelvic and lower-limb 3D parameters
Methodological detailssingle-centre, exact sex matching plus 1:1 nearest-neighbor propensity score matching for age and BMI, linear regression with matched-pair clustered robust SE, false discovery rate adjustment
- Single-centre
- Exact sex matching plus 1:1 nearest-neighbor propensity score matching for age and BMI
- Linear regression with matched-pair clustered robust SE
- False discovery rate adjustment
Main finding
As reported in the abstract
Β (HKA; greater varus alignment)
−3.72 °
95% CI −4.50 to −2.94
KOA
Β (sagittal flexion)
6.74 °
95% CI 5.58–7.90
KOA
Β (internal femorotibial rotation)
−2.95 °
95% CI −4.43 to −1.47
KOA
- Parameters differing after FDR adjustment
- 9 out of 17
Observational data: associations, not effects.
Further findings
Optimism-corrected AUC, demographic/coronal model vs adding sagittal parameters
- Demographic/coronal model AUC
- 0.691
- Adding sagittal parameters AUC
- 0.776
- Exploratory models
Original publication
Patients with knee osteoarthritis exhibit an abnormal three-dimensional lower limb phenotype: An EOS imaging study. Osteoarthritis Cartilage. Published 9 July 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →