Weight-Bearing Physical Activity, Lower-Limb Muscle Mass, and Risk of Knee Osteoarthritis
Authors' conclusion
The findings of this study suggest that weight-bearing activity is associated with incident knee osteoarthritis in people with low levels of lower-limb muscle mass, which might be a promising avenue for tailored advice for physical activity.
Study context
- Population
- Rotterdam Study (1996 to 2009) participants aged 45 years and older with knee x-ray at baseline and follow-up, without knee OA at baseline, Ommoord district, Rotterdam, The Netherlands9,483 knees
- Participants
- 5,003 participants
- Exposure
- Higher weight-bearing and non-weight-bearing recreational physical activity and incident knee OA
- Outcome
- Incident radiographic knee OA measured by knee x-ray
Methodological detailslogistic regression within generalized estimating equation framework, adjusted for potential confounders, prespecified stratification by LMI tertiles
- Logistic regression within generalized estimating equation framework
- Adjusted for potential confounders
- Prespecified stratification by LMI tertiles
Main finding
As reported in the abstract
Incident radiographic knee OA
Odds ratio (95% CI)P value
Weight-bearing activity
1.22(1.10–1.35)
P < 0.001Non-weight-bearing activity
1.04(0.95–1.15)
P = 0.37- Knee OA incident rate (793 of 9483 knees), mean (SD) follow-up 6.33 (2.46) years
- 8.4%
Observational data: associations, not effects.
Secondary outcomes
Incident knee OA with weight-bearing activity, lowest LMI tertile (prespecified stratification)
| OR (95% CI) | P value | ||
|---|---|---|---|
| Weight-bearing activity431 patients in the lowest LMI tertile | 1.53 (1.15–2.04) | P = 0.003 | |
| 0.512Odds ratio (log scale) |
- No association among patients in the middle or high LMI tertile
Original publication
Weight-Bearing Physical Activity, Lower-Limb Muscle Mass, and Risk of Knee Osteoarthritis. JAMA Netw Open. Published 1 April 2024. doi:10.
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