Evaluating the C-score from weight-bearing CT as a quantitative imaging biomarker for worsening knee osteoarthritis structure and pain in the multicenter osteoarthritis study
Main finding · Medial tibiofemoral JSN progression, per C-scoreResult — go to the resultOdds ratio 1.43 CI 1.07–1.92Authors' conclusion
In individuals with or at risk of knee OA, higher C-scores are moderately associated with medial-tibiofemoral JSN progression and worsening knee pain over 2-year-follow-up.
Study context
- Population
- Men and women with, and at increased risk for, symptomatic knee osteoarthritis (OA) (Multicenter Osteoarthritis Study); 56.3% females, mean age 63.8 years, BMI 28.5 kg/m²
- Participants
- 649 knees
- Outcome
- Association of baseline weight-bearing-CT (WBCT)-derived femoral C-score with worsening of OARSI JSN grade in the medial tibiofemoral compartment
- Follow-up
- 2 years
Methodological detailsmulticenter, generalized estimating equations adjusted for sex, age, >1 knee per participant, and BMI
- Multicenter
- Generalized estimating equations adjusted for sex, age, >1 knee per participant, and BMI
Main finding
Medial tibiofemoral JSN progression, per C-score
Odds ratio
1.43
CI 1.07–1.92
P = 0.01
C-score
OR 1.43 (CI 1.07–1.92); P = 0.01
Per C-score, as printed
As reported in the abstract
- Knees with medial tibiofemoral Joint-Space-Narrowing (JSN) worsening
- 70
Observational data: associations, not effects.
Further findings
| Outcome | OR (CI) | P value | |
|---|---|---|---|
| MCIW of pain (2 points on WOMAC pain subscore), per baseline C-score · 2 yearsAdjusted model | 1.27 (1.00–1.62) | P = 0.047 | |
| 0.512Odds ratio (log scale) |
Sex differences in associations
- Association with JSN progression more pronounced in men and with pain progression in women, but sex differences not statistically significant
- P > 0.05
Original publication
Evaluating the C-score from weight-bearing CT as a quantitative imaging biomarker for worsening knee osteoarthritis structure and pain in the multicenter osteoarthritis study. Osteoarthritis Cartilage. Published 29 September 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →