Moderators of the Effects of Exercise and Manual Therapy for People With Knee and Hip Osteoarthritis: A Secondary Analysis of a Randomized Clinical Trial
Authors' conclusion
Our findings suggest manual therapy may prove to be a more suitable treatment for people with higher BMI
Study context
- Population
- Patients with hip and/or knee OA (MOA trial)206 analysed
- Comparison
- Manual therapy and/or exercise therapy in addition to usual care vs usual care; moderators: Body mass index (BMI), pain self-efficacy, quadriceps strength, mental health, education
- Primary endpoint
- WOMAC composite score
- Follow-up
- One year
Methodological detailsmoderator analysis, linear regression models
- Moderator analysis
- Linear regression models
Primary result
As reported in the abstract
Moderation of treatment effects on WOMAC (β per one-unit increase in moderator; negative β = improvement)
- Manual therapy
- β, BMI moderation of WOMAC composite −4.1 (95% CI −6.6 to −1.7)
- Manual therapy
- β, BMI moderation of WOMAC function −3.3 (95% CI −5.1 to −1.6)
- Manual therapy
- β, BMI moderation of WOMAC pain −0.6 (95% CI −1.3 to 0.0)
- Manual therapy
- β, mental health moderation 16.8 (95% CI 2.2–31.4)
Original publication
Moderators of the Effects of Exercise and Manual Therapy for People With Knee and Hip Osteoarthritis: A Secondary Analysis of a Randomized Clinical Trial. Arthritis Care Res (Hoboken). Published 17 April 2026. doi:10.
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