Effects of neuromuscular control and strengthening exercises on MRI-measured thigh tissue composition and muscle properties in people with knee osteoarthritis – an exploratory secondary analysis from a randomized controlled trial
Authors' conclusion
Adding strength training to 12 weeks of neuromuscular control exercises provided largely similar effects to neuromuscular control exercises alone in decreasing InterMAT and IntraMAT, in improving knee-extensor strength, CSA and in improving performance-based function in KOA persons, with a trend towards greater effects with additional strength training.
Study context
- Population
- People with radiographic-symptomatic knee OAcomplete-case
- Participants
- 29 vs 34
- Comparison
- NEMEX plus quadriceps strength training vs NEMEX alone
- NEMEX+STn = 29
- NEMEXn = 34reference
- Primary endpoint
- MRI-measured InterMAT, IntraMAT, quadriceps CSA, knee-extensor strength, specific strength and 30 s chair-stands
- Follow-up
- 12 weeks
Methodological detailsexploratory, complete-case approach, mixed model analysis of variance
- Exploratory
- Complete-case approach
- Mixed model analysis of variance
Primary result
As reported in the abstract
Responses overall
- Responses to NEMEX+ST overlapped with NEMEX for all outcomes
Further findings
%
| Outcome | NEMEX+ST | NEMEX | Between-group difference (cm²) (95 % CI) | |
|---|---|---|---|---|
| InterMAT reduction · 12 weeks | 25 | 21 | 0.8 (−0.1 to 1.7) | |
| −1012Difference, cm² (linear scale) |
%
| Outcome | NEMEX+ST | NEMEX | Between-group difference (%-points) (CI) | |
|---|---|---|---|---|
| IntraMAT change (NEMEX+ST decreased, NEMEX increased) · 12 weeks | 2 | 4 | 0.1 (−0.3 to 0.5) | |
| −0.4−0.200.20.40.6Difference, %-points (linear scale) |
- IntraMAT change (NEMEX+ST decreased, NEMEX increased): NEMEX+ST decreased by 2 %; NEMEX increased by 4 %
Quadriceps cross-sectional area (CSA), lean CSA, knee-extensor strength, specific strength, chair-stand performance · 12 weeks
- Both groups improved, with a trend towards greater effects in NEMEX+ST
Original publication
Effects of neuromuscular control and strengthening exercises on MRI-measured thigh tissue composition and muscle properties in people with knee osteoarthritis – an exploratory secondary analysis from a randomized controlled trial. Semin Arthritis Rheum. Published 3 February 2024. doi:10.
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