Diagnostic Accuracy of Candidate Magnetic Resonance Imaging Knee Osteoarthritis Definitions Versus Radiograph in an Acute Anterior Cruciate Ligament Injury Cohort
Authors' conclusion
Simple MRI-based OA definitions requiring at least cartilage damage and an osteophyte have low sensitivity and high specificity in young persons after knee injury.
Study context
- Population
- Participants 5 years after acute anterior cruciate ligament (ACL) injury with knee radiographs and magnetic resonance imaging (MRI) (mean age 26 years, 26% female)29 (26%) with Radiographic OA (ROA)
- Participants
- 113 participants
- Comparison
- Three candidate MRI osteoarthritis (OA) definitions vs radiographic OA
- Outcome
- Sensitivity and specificity of each MRI OA definition vs ROA
- Follow-up
- 5 years
Methodological detailsMRI OA definitions vs radiographic OA reference
- MRI OA definitions vs radiographic OA reference
Performance
As reported in the abstract
Diagnostic accuracy vs ROA
| Test or model | Sensitivity | Specificity |
|---|---|---|
| Multicenter Osteoarthritis Study (MOST) simple | 52% (95% CI 33%-71%)Sensitivity on a scale from 0 to 100 percent | 76% (95% CI 66%-85%)Specificity on a scale from 0 to 100 percent |
| MOST optional | 28% (95% CI 29%-67%) | 83% (95% CI 74%-91%)Specificity on a scale from 0 to 100 percent |
| Delphi panel definition | 48% (95% CI 29%-67%)Sensitivity on a scale from 0 to 100 percent | 77% (95% CI 67%-86%)Specificity on a scale from 0 to 100 percent |
Sensitivity
Multicenter Osteoarthritis Study (MOST) simple52% (95% CI 33%-71%)
MOST optional28% (95% CI 29%-67%)
Delphi panel definition48% (95% CI 29%-67%)
Sensitivity on a scale from 0 to 100 percentSpecificity
Multicenter Osteoarthritis Study (MOST) simple76% (95% CI 66%-85%)
MOST optional83% (95% CI 74%-91%)
Delphi panel definition77% (95% CI 67%-86%)
Specificity on a scale from 0 to 100 percentOriginal publication
Diagnostic Accuracy of Candidate Magnetic Resonance Imaging Knee Osteoarthritis Definitions Versus Radiograph in an Acute Anterior Cruciate Ligament Injury Cohort. Arthritis Care Res (Hoboken). Published 17 December 2023. doi:10.
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