Association of Knee Osteoarthritis and Flexion Contracture With Localized Tibial Articular Cartilage Loss: Data From the Osteoarthritis Initiative
Authors' conclusion
Knee FC unloading the tibial center region and loading the posterior region was associated with localized articular cartilage loss centrally and preserved articular cartilage posteriorly.
Study context
- Population
- People with radiographic knee OA with or without progression, based on radiographs and symptoms (Osteoarthritis Initiative)
- Participants
- 578 people
- Comparison
- Knee flexion contracture vs no flexion contracture
- Outcome
- Localized changes in tibial articular cartilage thickness or percent of denuded bone (0 mm thickness), medial and lateral condyles (anterior, center, posterior regions), on MRI
- Follow-up
- 1 year
Methodological detailsOsteoarthritis Initiative quantitative data, ANOVA controlling for baseline magnetic resonance imaging (MRI) outcomes and clinical factors
- Osteoarthritis Initiative quantitative data
- ANOVA controlling for baseline MRI outcomes and clinical factors
Main finding
As reported in the abstract
Localized tibial cartilage change after 1 year
β
0.44
95% CI 0.02–0.86
denuded bone, medial condyle center
β
0.01
95% CI 0.002–0.03
preserved cartilage thickness, medial condyle posterior
Observational data: associations, not effects.
Original publication
Association of Knee Osteoarthritis and Flexion Contracture With Localized Tibial Articular Cartilage Loss: Data From the Osteoarthritis Initiative. J Rheumatol. Published 15 December 2023. doi:10.
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