Gender differences in patterns of cartilage loss: Data from the Osteoarthritis Initiative
Authors' conclusion
The LACS method was capable of illustrating gender-specific differences in patterns of cartilage loss that may offer insight into the variation of gender differences in the natural history of KOA and may be useful in evaluating the benefit of interventions for KOA.
Study context
- Population
- Subjects with Kellgren-Lawrence 1, 2 or 3 knees from the Osteoarthritis Initiative
- Participants
- 700 subjects
- Exposure
- Women vs men
- Outcome
- Gender differences in patterns of cartilage loss in the central weight-bearing regions of the femur (cartilage volume change)
- Follow-up
- BL to 24, 48, 72 and 96 mo
Methodological detailslocal area cartilage segmentation (LACS) method, responsiveness heat maps
- Local area cartilage segmentation (LACS) method
- Responsiveness heat maps
Main finding
As reported in the abstract
Cartilage change by gender
- Statistically significant gender difference in cartilage change in the medial femur, lateral femur and medial tibia
- Loss primarily in the posterior central weight-bearing portion of the lateral femur (LF) and more general in the LT and medial femur (MF)
- Similar patterns for each of the four follow-up periods
Observational data: associations, not effects.
Original publication
Gender differences in patterns of cartilage loss: Data from the Osteoarthritis Initiative. Osteoarthritis Cartilage. Published 29 April 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →