Gender and age differences in the associations between cortical thickness and hand osteoarthritis severity: data from the Osteoarthritis Initiative
Authors' conclusion
We found significant HOA-related gender differences in Tcort, suggesting the involvement of female bone loss during and after menopause.
Study context
- Population
- Osteoarthritis Initiative participants with hand radiographs at baseline and 48 months
- Participants
- 3,575 participants
- Exposure
- Women vs men, across age groups
- Fn = 2,039
- Mn = 1,536reference
- Outcome
- Association between metacarpal cortical thickness (Tcort) and severity of radiographic hand OA, by gender
Methodological detailsstratified by gender and 5-year age groups, Spearman's rank correlation, logistic regression
- Stratified by gender and 5-year age groups
- Spearman's rank correlation
- Logistic regression
Main finding
As reported in the abstract
Correlation of baseline Tcort with radiographic hand osteoarthritis (HOA) severity
Correlation in women >60 years (rho)
−0.25
95% CI −0.31 to −0.19
Observational data: associations, not effects.
Further findings
| Outcome | F | M | P value |
|---|---|---|---|
| Tcort change and radiographic OA change · 48 months | −0.219 (unspecified 0.124) | −0.182 (unspecified 0.118) | P < 0.01 |
- Tcort change and radiographic OA change: per-group values: Tcort change ages 55 to <60
Tcort change and radiographic OA change · 48 months
- Significant associations between Tcort change and radiographic OA change in women but not men
Original publication
Gender and age differences in the associations between cortical thickness and hand osteoarthritis severity: data from the Osteoarthritis Initiative. Osteoarthritis Cartilage. Published 18 May 2024. doi:10.
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